I applied for the first time during my internship year (I'm in clinical) and got 0 interviews. I don't remember how many places I applied to, but less than 10 and I knew it was a long shot. I took a clinical research postdoc and applied again for 2 more cycles. Agree with the person upthread who said it gets better every year, both in outcomes per application and in the quality of places that were interested in me. It really does suck to do it over and over, though, and I'm really lucky that I had my own funding, so I could stay employed, and a supportive/flexible partner.
year 1: 2 phone/2 campus/13 applications (no offers)
year 2: 11 phone/2 campus/40+ applications (1 offer)
I applied to R1/R2 places with graduate programs in my area with no geographic restrictions. I also applied to some med schools that had TT positions. I should add that I withdrew from three searches before campus interviews and heard from another place that appeared to be dipping back into its pool for campus interviews after I accepted my offer.